His success earned him a promotion to the 250cc class with Giacomo Agostini's Marlboro Yamaha factory racing team in 1986. In 1991, Cadalora switched to the Rothmans Honda factory racing team and won the 250cc World Championship aboard an Erv Kanemoto-tuned Honda NSR250.
He successfully defended his title with Honda in 1992, claiming his third world championship. In 1993 he rose to the premier 500cc division as Wayne Rainey's teammate in the Kenny Roberts-Yamaha team. In three seasons on the Roberts Yamaha, he displayed flashes of brilliance, finishing as high as second to Mick Doohan in 1994.
Cadalora rejoined Kanemoto for the 1996 season racing a Honda NSR500. Despite lacking any major sponsors, he still managed to finish the season in third place aboard the Kanemoto-Honda.For the 1997 season, he got a contract as official Yamaha rider in the new Promotor Racing team backed by an Austrian businessman. However, after few races the team failed due to financial problems. WCM rescued the team with the help of a Red Bull sponsorship and Cadalora ended the season in sixth place. At the beginning of the 1998 season, WCM and Cadalora lost Yamaha official support.
In 1999 he was again with MuZ. Cadalora finished his career with Kenny Roberts' Modenas team in 2000. He retired with 34 Grand Prix victories in three different classes. The item "Arai Luca Cadalora Helmet M Vintage Rare Italian Flag Colors Yamaha GP" is in sale since Thursday, October 22, 2020. This item is in the category "eBay Motors\Parts & Accessories\Apparel, Protective Gear & Merchandise\Helmets & Accessories\Motorcycle & Powersport Helmets".The seller is "sanescientist" and is located in Aptos, California. This item can be shipped to United States, Canada, United Kingdom, Denmark, Romania, Slovakia, Bulgaria, Czech republic, Finland, Hungary, Latvia, Lithuania, Malta, Estonia, Australia, Greece, Portugal, Cyprus, Slovenia, Japan, China, Sweden, South Korea, Indonesia, Taiwan, Thailand, Belgium, France, Hong Kong, Ireland, Netherlands, Poland, Spain, Italy, Germany, Austria, Bahamas, Mexico, New Zealand, Philippines, Singapore, Switzerland, Norway, Ukraine, Croatia, Chile, Colombia, Costa rica, Panama, Trinidad and tobago, Guatemala, Honduras, Jamaica, Antigua and barbuda, Aruba, Belize, Dominica, Grenada, Saint kitts and nevis, Saint lucia, Montserrat, Turks and caicos islands, Barbados, Bangladesh, Bermuda, Brunei darussalam, Bolivia, French guiana, Guernsey, Gibraltar, Guadeloupe, Iceland, Jersey, Cambodia, Cayman islands, Liechtenstein, Sri lanka, Luxembourg, Monaco, Macao, Martinique, Maldives, Nicaragua, Pakistan, Paraguay, Uruguay, Russian federation.